School of Medicine

Wayne State University School of Medicine

Metabolism, Obesity and Diabetes

The Center for Integrative Metabolic and Endocrine Research (CIMER) is a joint research effort of the Departments of Psychiatry and Behavioral Neurosciences, Pathology and Internal Medicine (Endocrinology) that was established to address the world-wide epidemic of obesity and diabetes. CIMER researchers are dedicated to an integrative analysis of neuro/behavioral, cellular and biochemical bases of obesity and obesity-related disorders. CIMER investigators conduct basic research with the goal of identifying and developing new molecular targets for treatment of metabolic diseases.

CIMER Principal Investigators

James Granneman
Professor of Psychiatry
Research Interests: Adipose tissue cell and molecular biology, target identification and high through-put screening for novel obesity and diabetes therapeutics.

Selected Publications

Granneman JG. Delivery of DNA into adipocytes within adipose tissue. Methods Mol Biol. 2008;423:191-5. PMID: 18370199 [PubMed - indexed for MEDLINE]

Granneman JG, Moore HP. Location, location: protein trafficking and lipolysis in adipocytes. Trends Endocrinol Metab. 2008 Jan;19(1):3-9. Epub 2007 Dec 26. Review. PMID: 18155916 [PubMed - indexed for MEDLINE]

Mottillo EP, Shen XJ, Granneman JG. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1188-97. Epub 2007 Aug 21. PMID: 17711991 [PubMed - indexed for MEDLINE]

Granneman JG, Moore HP, Granneman RL, Greenberg AS, Obin MS, Zhu Z. Analysis of lipolytic protein trafficking and interactions in adipocytes. J Biol Chem. 2007 Feb 23;282(8):5726-35. Epub 2006 Dec 21. PMID: 17189257 [PubMed - indexed for MEDLINE]

Moore HP, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem. 2005 Dec 30;280(52):43109-20. Epub 2005

Todd Leff
Associate Professor of Pathology.
Research Interests: Regulation of gene expression in metabolic diseases such as obesity and type-2 diabetes.

Melissa Lingohr
Assistant Professor of Pathology
Research Interests: Pancreatic beta cell biology, in vitro and in vivo analysis of stem cells and beta cell progenitors.

Robert MacKenzie
Associate Professor of Psychiatry
Research Interests: Neural control of metabolism and feeding behavior, development and analysis of neuron-specific transgenic mouse models.

Selected Publications

VanLeewen, D, Steffey , ME , Donahue, C, Ho, G and MacKenzie, RG. Cell surface expression of the melanocortin-4 receptor is dependent on a C-terminal di-isoleucine sequence at codons 316/317. J. Biol. Chem. 2003; 278: 15935-15940.

RG MacKenzie. Signaling in obesity neurons. Current Medicinal Chemistry. 2004; 4: 113-117.

Yao F, Yu F, Gong L, Taube D, Rao DD, MacKenzie RG. Microarray analysis of fluoro-gold labeled dopamine neurons harvested by laser capture microdissection. J. Neurosci. Methods, 2005; 143: 95-106.

Kaelin CB, Gong L, Xu AW, Yao F, Hockman K, Morton GJ, Schwartz MJ, Barsh GS, and MacKenzie RG. Stat binding sites but not Stat3 are required for fasting-induced transcription of Agouti-related protein mRNA. Molec. Endocrinology, 2006; 20: 2591-2602.

RG MacKenzie. Obesity-Associated Mutations in the Human Melanocortin-4 Receptor Gene: A Review. Peptides. 2006; 27:395-403.

Esther van de Wall, Rebecca Leshan, Allison W. Xu, Nina Balthasar, Roberto Coppari, Shun Mei Liu, Robert G. MacKenzie, David B. Allison, Nae Dun, Joel Elmquist, Bradford Lowell, Greg Barsh, Martin Myers, Jr., Gary J. Schwartz and Streamson C. Chua, Jr Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion. Endocrinology, 2007; 149: 1773-1785.

Lijie Gong, Fayi Yao, Kristin Hockman, Henry H. Heng, Gregory J. Morton, Kiyoshi Takeda, Shizuo Akira, Malcolm J. Low, Marcelo Rubinstein and Robert G. MacKenzie. Stat3 is required in hypothalamic Agrp/Npy neurons for normal energy homeostasis. Endocrinology, 2008; 149: 3346-3354.