Jeffrey Stanley
Position Title
Professor
Office Address
Tolan Park
Detroit, MI 48201
Office Phone
313-577-9090
Biography
Jeffrey A. Stanley, PhD, is a neuroimaging scientist with over 25 years of research experience in furthering the understanding of neural mechanisms underlying brain development and aging as well as different psychiatric disorders including schizophrenia, at risk populations for schizophrenia, ADHD, and mood disorders. Through the use of different innovative Magnetic Resonance Imaging (MRI) methodologies including Magnetic Resonance Spectroscopy (MRS), functional MRS, quantitative structural MRI and myelin water imaging, Dr. Stanley has made significant contributions from the perspective of brain chemistry, function, myelin microstructure and morphology to the field of Psychiatry.
Specialty:
- Assessing glutamate modulation related to task using functional ¹H MRS
- Assessing the in vivo myelin microstructure of white matter tracts using myelin water imaging
- Structural MR imaging using T₁ and T₂ mapping methods
- In vivo ¹H and ³¹P MRS
- Brain development and aging
Education Training
- B.S. in Physics (1987) - University of Waterloo, Waterloo, Ontario
- M.S. in Physics (1990) - University of Waterloo, Waterloo, Ontario
- Ph.D. in Medical Biophysics (1994) - University of Western Ontario, London, Ontario
- Postdoc (1994-1995) - Montreal Neurological Institute, Montreal, Quebec
- Fellow (1996-1998) - Western Psychiatric Institute and Clinic, Pittsburgh
Current Positions and Employment
- 2004 - present: Adjunct Assistant Professor, Dept. of Psychiatry, U. of Pittsburgh SOM, Pittsburgh, PA.
- 2005 - present: Graduate Faculty Member, Wayne State University School of Graduate, Detroit, MI.
- 2008 - present: Co-Director, Brain Imaging Research Division, WSU SOM, Detroit, MI
- 2010 - present: Director of the Translational Neuroscience Program (TNP), WSU, Detroit, MI.
- 2010 - present: Tenure in the Department of Psychiatry & Behavioral Neurosciences, WSU SOM, Detroit, MI
- 2010 - present: Adjunct Associate Professor of Biomedical Engineering, WSU, Detroit, MI
- 2017 - present: Professor, Dept. of Psychiatry and Behavioral Neurosciences, WSU SOM, Detroit, MI
Research Interests
- Understanding the neural basis of learning and memory deficits in schizophrenia from the perspective NMDA-mediated modulation of hippocampal glutamate using functional ¹H MRS.
- Understanding the neural basis of glutamate neural dysfunction in the hippocampus underlying age-related cognitive deficits in learning and memory using functional ¹H MRS.
- Understanding the relationship between age-related changes in the brain and cognition and to examine the mechanisms that may underlie these associations from the perspective brain energy metabolism and myelination of subcortical and cortical areas.
- Understanding of the synaptic organization and integration of glutamatergic excitatory and GABAergic inhibitory (E/I) microcircuits that play a key role in regulating the excitability of cortex and hence, cortical function. Imbalances in E/I synaptic drive are thought to be fundamental contributors to network dysfunctions associated with symptoms and behavioral/cognitive impairments in psychiatric disorders. Research includes investigating task-related changes in brain glutamate under different cognitive conditions using functional MRS, which provides a sensitive and insightful tool for investigating disruptions to the E/I synaptic drive in neuropsychiatric disorders such as in schizophrenia.
Laboratory Web Site
Brain Imaging Research Division Lab